ERRATUM: FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD

نویسندگان

  • Yusuke Fujioka
  • Shinsuke Ishigaki
  • Akio Masuda
  • Yohei Iguchi
  • Tsuyoshi Udagawa
  • Hirohisa Watanabe
  • Masahisa Katsuno
  • Kinji Ohno
  • Gen Sobue
چکیده

The details for affiliation 1 were incorrect in the original HTML version of this Article. The affiliation was incorrectly listed as ‘‘Department of Neurology, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan’’. The correct affiliation is listed above. This has now been corrected in the HTML version of the Article. SUBJECT AREAS: DEMENTIA CELLULAR NEUROSCIENCE MOTOR NEURON DISEASE ALTERNATIVE SPLICING

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FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD

FUS is genetically and pathologically linked to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). To clarify the RNA metabolism cascade regulated by FUS in ALS/FTLD, we compared the FUS-regulated transcriptome profiles in different lineages of primary cells from the central nervous system. The profiles of FUS-mediated gene expression and alternative splicing in m...

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The FUS gene has been linked to amyotrophic lateral sclerosis (ALS). FUS is a ubiquitous RNA-binding protein, and the mechanisms leading to selective motoneuron loss downstream of ALS-linked mutations are largely unknown. We report the transcriptome analysis of human purified motoneurons, obtained from FUS wild-type or mutant isogenic induced pluripotent stem cells (iPSCs). Gene ontology analys...

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The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons☆

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عنوان ژورنال:

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2013